Description
| Indications | Listed in Dosage. |
| Dosage | Adult : Ophth Conjunctival decongestant As 0.05-0.1% soln: Instill as directed. Nasal Nasal congestion As 0.1% soln: Instill into each nostril 2-3 times/day. Max duration: 7 days. |
| Dosage Details | Nasal Nasal congestion Adult: As 0.1% solution: Instill into each nostril bid-tid. Max duration: 7 days.
Ophthalmic Adult: As 0.05-0.1% solution: Instil into the eye. |
| Contraindications | Angle closure glaucoma; dry rhinitis; post trans-sphenoidal hypophysectomy, trans-nasal, trans-oral surgery where dura mater is exposed. |
| Special Precautions | Young children, pregnancy and lactation. Hypertension, CV abnormalities, DM, hyperthyroidism, history of excessive reaction to sympathomimetics, difficulty in urination secondary to prostate enlargement. Rebound congestion may occur after prolonged regular use. |
| Adverse Drug Reactions | Headache, insomnia, tachycardia, hypertension, nervousness, nausea, dizziness, palpitation, arrhythmia. Nasal drops: Local stinging or burning, sneezing, dryness of mouth and throat, nausea. Eye drops: Dryness of eye. |
| Drug Interactions | Increased heart rate or BP with sibutramine. Potentially Fatal: Hypertensive crisis with MAOIs. |
| Mechanism of Action | Description: Xylometazoline is a direct-acting sympathomimetic which has a vasoconstrictor effect by reducing swelling and congestion when applied to mucous membranes. Onset: 5-10 min. Duration: 10 hr. |
| Storage | Store below 30°C. |
| MIMS Class | Nasal Decongestants & Other Nasal Preparations / Ophthalmic Decongestants, Anesthetics, Anti-Inflammatories |
