Indications
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Listed in Dosage. |
Dosage
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Adult : PO Vit K deficiency10 mg 6 hrly. Severe hypoprothrombinaemia 10 mg 3-4 times/day. IV Vit K Deficiency 0.03 mcg/kg/day. IM Haemorrhage or threatened haemorrhage during severe hypoprothrombinaemia 2.5-10 mg/day. |
Dosage Details
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Intramuscular
Severe hypoprothrombinaemia
Adult: 2.5-10 mg daily.
Intravenous
Vitamin K deficiency
Adult: 0.03 mcg/kg/day.
Child: Infants: 1-5 mcg/kg/day.
Oral
Severe hypoprothrombinaemia
Adult: 10 mg 3-4 times daily.
Oral
Vitamin K deficiency
Adult: 10 mg every 6 hr.
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Special Precautions
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Pregnancy. G6PD deficiency, vitamin E deficiency. Neonates, premature infants. Hepatic impairment. Monitor prothrombin time. |
Adverse Drug Reactions
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Facial flushing, sweating, chest constriction/pain, dyspnoea, cyanosis, CV collapse. IM: Severe shock-like reactions, phlebitis, inj site reactions.
Potentially Fatal: Anaphylaxis. |
Drug Interactions
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Decreases effects of oral anticoagulants.
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Mechanism of Action
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Description: Menadione is a synthetic lipid-soluble vitamin K analogue. It is an essential cofactor in the hepatic synthesis of prothrombin (factor II) and other blood clotting factors (factors VII, IX, X and proteins C and S), and in the function of proteins important for bone development (e.g. osteocalcin).
Pharmacokinetics:
Absorption: Requires bile for absorption from the GI tract.
Distribution: Accumulates in the liver; does not appear to cross the placenta. |
