Description
Mechanism of Action
Tobramycin acts by binding to 30S ribosomal subunits thus interfering with bacterial protein synthesis. It is active against many aerobic gram-negative bacteria and some aerobic gram-positive bacteria but inactive against Chlamydia, fungi, viruses, and most anaerobic bacteria.
Absorption: Rapid and complete absorption (IM); peak plasma concentrations after 30-90 min (IM). Poor oral absorption.
Distribution: Crosses the placenta.
Excretion: Via the urine; elimination half-life: 2-3 hr.
MIMS Class
Eye Anti-Infectives & Antiseptics / Aminoglycosides
ATC Classification
S01AA12 – tobramycin; Belongs to the class of antibiotics. Used in the treatment of eye infections.;
J01GB01 – tobramycin; Belongs to the class of other aminoglycosides. Used in the systemic treatment of infections.;
