Description
Indications |
Ocular inflammation with suspected or confirmed bacterial infection. | ||||||||||||||||||
Dosage |
Adult : Ophth As susp containing tobramycin 0.3% and dexamethasone 0.1%: Instill 1-2 drops 4-6 hrly. May increase to 2 hrly during the initial 24-48 hr, reduce frequency gradually as improvement seen. As oint containing tobramycin 0.3% and dexamethasone 0.1%: Apply half an inch ≤3-4 times/day. | ||||||||||||||||||
Dosage Details |
Ophthalmic Ocular inflammation with suspected or confirmed bacterial infection Adult: As suspension containing tobramycin 0.3% and dexamethasone 0.1%: 1-2 drops instilled into the conjunctival sac(s) 4-6 hrly. Dosage may be increased to every 2 hrly during the initial 24-48 hr, decrease frequency gradually as improvement seen. As ointment containing tobramycin 0.3% and dexamethasone 0.1%: Apply about ½ inch of ointment into the conjunctival sac(s) up to 3-4 times daily. |
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Contraindications |
Viral infections of corneal and conjunctiva (e.g. epithelial herpes simplex keratitis, vaccinia, varicella). Mycobacterial or fungal infection of the eye. | ||||||||||||||||||
Special Precautions |
Pregnancy and lactation. Avoid prolonged use, monitor intraocular pressure routinely. Safety and effectiveness in children <2 yr not established. | ||||||||||||||||||
Adverse Drug Reactions |
Hypersensitivity reactions, lid itching and swelling, conjunctival erythema, increase in intraocular pressure, glaucoma, optic nerve damage, posterior subcapsular cataract formation and delayed wound healing. Secondary infections especially after prolonged use. | ||||||||||||||||||
Pregnancy Category (US FDA) |
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus. |
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Mechanism of Action |
Description: Tobramycin, an aminoglycoside antibiotic, has actions similar to that of gentamicin and is active against Staphylococci, Streptococci, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morganella morganii, most Proteus vulgarisstrains, Haemophilus influenzae and H. aegyptius, Moraxella lacunata, Acinetobacter calcoaceticus and some Neisseria species. Dexamethasone, a synthetic fluorinated corticosteroid, has mainly glucocorticoid activity and suppresses inflammatory response. | ||||||||||||||||||
Storage |
Suspension: Store between 8-27°C (46-80°F); shake well before using. Ointment: Store between 8-27°C (46-80°F). | ||||||||||||||||||
MIMS Class |
Eye Antiseptics with Corticosteroids | ||||||||||||||||||
