Description
Mechanism of Action
Piperacillin inhibit septum and cell wall synthesis and has an antimicrobial activity against a wide range of gm-ve organisms including K. pneumoniae, P. aeruginosa, Enterobacteriaceae and against Garm-positive organisms eg, E. faecalis and B. fragilis.
Absorption: Not absorbed when given orally. IM: well absorbed with peak plasma concentrations after 30-50 min.
Distribution: Widely distributed into body tissues and fluids, CSF (small amounts except when the meninges are inflamed), bile (high concentrations); crosses the placenta and enters the breast milk. Protein-binding: 20%
Excretion: Via the urine by glomerular filtration and tubular secretion (60-80% unchanged), via the bile (20%); may be removed by dialysis. Elimination half-life: 1 hr; 4-6 hr (end-stage renal failure), 3-fold increase (severe renal insufficiency), prolonged in neonates and in renal and hepatic impairment.
MIMS Class
Penicillins
ATC Classification
J01CA12 – piperacillin; Belongs to the class of penicillins with extended spectrum. Used in the systemic treatment of infections
