Description
Mechanism of Action
Pioglitazone is as a potent and highly selective agonist for the peroxisome proliferator activated receptor-γ (PPAR-γ). Activation of these receptors promotes the production of gene products involved in lipid and glucose metabolism. It also improves insulin response to target cells w/o increasing the pancreatic secretion of insulin.
Onset: Delayed.
Absorption: Rapidly absorbed. Bioavailability: >80%. Time to peak plasma concentration: Approx 2 hr.
Distribution: Volume of distribution: 0.63 L/kg. Plasma protein binding: >99% (mainly to albumin).
Metabolism: Extensive hepatic metabolism via CYP2C8 and CYP3A4 isoenzymes to its active and inactive metabolites.
Excretion: Via urine (15-30%); faeces (as metabolites). Elimination half-life: 3-7 hr (parent drug).
MIMS Class
Antidiabetic Agents
ATC Classification
A10BG03 – pioglitazone; Belongs to the class of thiazolidinediones. Used in the treatment of diabetes
