Ofloxacin Tablet 400mg (FLOXA-400 *) 100s

431.00

Only 8 left in stock (can be backordered)

SKU: 06142013113156 Category:

Description

Mechanism of Action
Ofloxacin is a fluoroquinolone which inhibits bacterial topoisomerase IV and DNA gyrase enzymes required for DNA replication, transcription, repair and recombination. It has activity against a wide range of gram-negative and gram-positive microorganisms.
Absorption: Rapidly and well absorbed from the GI tract (oral); peak plasma concentrations after 0.5-2 hr. Rate, but not extent, delayed by the presence of food.
Distribution: Widely distributed into body fluids, CSF, tissues, bile (high concentrations); crosses the placenta and enters breast milk. Protein-binding: 20-32%.
Metabolism: <10% of a single dose is metbolised. Converted to desmethyl and N-oxide metabolites; desmethylofloxacin has moderate antibacterial activity.
Excretion: Via urine within 24-48 hr by tubular secretion and glomerular filtration (75-80% as unchanged, <5% as metabolites); via faeces (4-8%). Elimination is biphasic with half-lives of 4-5 hr and 20-25 hr; prolonged in renal impairment (15-60 hr).

MIMS Class
Eye Anti-Infectives & Antiseptics  /  Quinolones  /  Ear Anti-Infectives & Antiseptics 

ATC Classification
J01MA01 –  ofloxacin;  Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.;  
S02AA16 –  ofloxacin;  Belongs to the class of antiinfectives used in the treatment of ear infections.;  
S01AE01 –  ofloxacin;  Belongs to the class of quinolone antiinfectives. Used in the treatment of eye infections.;  

Additional information

Weight 79 g
Dimensions 11.1 × 4.3 × 6.3 cm
location

davao, cdo, dipolog, butuan