Description
Mechanism of Action
Norfloxacin inhibits the action of DNA gyrase in DNA replication, transcription, repair, recombination and transposition.
Absorption: 30-40% absorbed from the GI tract (oral); peak plasma concentrations after 1-2 hr. May be delayed by the presence of food.
Distribution: Genitourinary tract, placenta, bile (high concentrations). Protein-binding: 14%.
Metabolism: Hepatic; converted to several metabolites with antibacterial activity.
Excretion: Via urine by glomerular filtration and tubular secretion within 24 hr (30% as unchanged); via faeces (30%); 4 hr (elimination half-life); may be prolonged in renal impairment.
MIMS Class
Eye Anti-Infectives & Antiseptics / Quinolones
ATC Classification
J01MA06 – norfloxacin; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.;
S01AE02 – norfloxacin; Belongs to the class of quinolone antiinfectives. Used in the treatment of eye infections.
