Mefenamic Acid Tablet 500mg (MEFESAPH *) 100s

126.00

Only 3 left in stock (can be backordered)

SKU: 07242020040632 Category:

Description

Mechanism of Action
Mefenamic acid, an anthranilic acid derivative, is a prototypical NSAID. It reversibly inhibits the cyclooxygenase-1 and -2 (COX-1 and -2) enzymes, thus resulting in reduced synthesis of prostaglandin precursors. It has analgesic and antipyretic properties w/ minor anti-inflammatory activity.
Duration: ≤6 hr.
Absorption: Rapidly absorbed from the GI tract. Time to peak plasma concentration: Approx 2-4 hr.
Distribution: Enters breast milk (small amounts). Volume of distribution: 1.06 L/kg. Plasma protein binding: >90%.
Metabolism: Metabolised by CYP2C9 isoenzyme to 3-hydroxymethyl mefenamic acid, which may then be oxidised to 3-carboxymefenamic acid.
Excretion: Via urine (approx 52%) as unchanged drug and metabolites; faeces (approx 20%). Elimination half-life: Approx 2-4 hr.

MIMS Class
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) 

ATC Classification
M01AG01 –  mefenamic acid;  Belongs to the class of non-steroidal antiinflammatory and antirheumatic products, fenamates.;

Additional information

location

davao, cdo, dipolog, butuan