Description
Mechanism of Action
Hydralazine is a direct-acting vasodilator which acts predominantly on the arterioles. It reduces BP and peripheral resistance but produces fluid retention. Hydralazine tends to improve renal and cerebral blood flow and its effect on diastolic pressure is more marked than on systolic pressure.
Onset: Oral: 45 min. IV: 10-20 min.
Duration: Oral and IV: 3-8 hr.
Absorption: Rapidly absorbed from the GI tract after oral admin.
Distribution: About 90% bound to plasma proteins.
Metabolism: Undergoes considerable first-pass metabolism by acetylation in the GI mucosa and liver.
Excretion: Mainly excreted in urine as metabolites.
MIMS Class
Other Antihypertensives
ATC Classification
C02DB02 – hydralazine; Belongs to the class of hydrazinophthalazine derivatives. Used in the treatment of hypertension.
