Description
Mechanism of Action
Glipizide stimulates insulin release from pancreatic β-cells and reduces gluconeogenesis in liver cells. It also increases insulin sensitivity at target sites.
Duration: 24 hr.
Absorption: Readily absorbed from the GI tract (oral); peak plasma concentrations after 1-3 hr.
Distribution: Protein-binding: Extensive.
Metabolism: Hepatic.
Excretion: Urine (as inactive metabolites); faeces; 2-4 hr (elimination half-life).
MIMS Class
Antidiabetic Agents
ATC Classification
A10BB07 – glipizide; Belongs to the class of sulfonamides, urea derivatives. Used in the treatment of diabetes.;
