Description
Mechanism of Action
Glibenclamide exerts pancreatic and extrapancreatic actions. It stimulates an increase in insulin release by the pancreatic β-cells. It may also reduce hepatic gluconeogenesis and glycogenolysis. Increased glucose uptake in the liver and utilization in the skeletal muscles.
Duration: 24 hr.
Absorption: Readily absorbed from the GI tract (oral); peak plasma concentrations after 2-4 hr.
Distribution: Protein-binding: Extensive.
Metabolism: Hepatic; converted to very weakly active metabolite.
Excretion: Urine (50%); faeces (50%).
MIMS Class
Antidiabetic Agents
ATC Classification
A10BB01 – glibenclamide; Belongs to the class of sulfonamides, urea derivatives. Used in the treatment of diabetes.;
