Description
Mechanism of Action
Gentamicin is an aminoglycoside that binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective.
Absorption: Poorly absorbed from the GI tract (oral); rapid (IM); systemic absorption from denuded skin and burns (topical) and from wounds, body cavities, joints (instillation, irrigation).
Distribution: Diffuse mainly into the extracellular fluids; but only small amounts enter the CSF even when the meninges are inflamed. Poorly diffused (Ophthalmic), readily diffused (perilymph of the inner ear). Crosses the placenta and enters the breast milk. Accumulates mainly in the kidneys.
Excretion: Via the urine by glomerular filtration (virtually unchanged); 2-3 hr (elimination half-life).
Gentamicin is an aminoglycoside that binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective.
Absorption: Poorly absorbed from the GI tract (oral); rapid (IM); systemic absorption from denuded skin and burns (topical) and from wounds, body cavities, joints (instillation, irrigation).
Distribution: Diffuse mainly into the extracellular fluids; but only small amounts enter the CSF even when the meninges are inflamed. Poorly diffused (Ophthalmic), readily diffused (perilymph of the inner ear). Crosses the placenta and enters the breast milk. Accumulates mainly in the kidneys.
Excretion: Via the urine by glomerular filtration (virtually unchanged); 2-3 hr (elimination half-life).
MIMS Class
Eye Anti-Infectives & Antiseptics / Topical Antibiotics / Aminoglycosides / Ear Anti-Infectives & Antiseptics
ATC Classification
S01AA11 – gentamicin; Belongs to the class of antibiotics. Used in the treatment of eye infections.;
S02AA14 – gentamicin; Belongs to the class of antiinfectives used in the treatment of ear infections.;
S03AA06 – gentamicin; Belongs to the class of antiinfectives used in ophthalmologic and otologic preparations.;
D06AX07 – gentamicin; Belongs to the class of other topical antibiotics used in the treatment of dermatological diseases.;
J01GB03 – gentamicin; Belongs to the class of other aminoglycosides. Used in the systemic treatment of infections.;
