Description
Mechanism of Action
Domperidone is a peripheral dopamine-receptor blocker. It increases oesophageal peristalsis, enhances gastroduodenal coordination and lowers oesophageal sphincter pressure, gastric motility and peristalsis, thus facilitating gastric emptying and decreasing small bowel transit time.
Absorption: Rapidly absorbed. Food may delay absorption. Bioavailability: Approx 15% (oral and rectal). Time to peak plasma concentration: Approx 30 min (oral); approx 1 hr (rectal).
Distribution: Enters breast milk (small amounts). Plasma protein binding: >90%.
Metabolism: Undergoes rapid and extensive hepatic metabolism via N-dealkylation by CYP3A4 isoenzyme and hydroxylation by CYP3A4, CYP1A2 and CYP2E1 isoenzymes.
Excretion: Via urine (approx 30%, as metabolites); faeces (approx 10%, as unchanged drug). Elimination half-life: Approx 7.5 hr.
Domperidone is a peripheral dopamine-receptor blocker. It increases oesophageal peristalsis, enhances gastroduodenal coordination and lowers oesophageal sphincter pressure, gastric motility and peristalsis, thus facilitating gastric emptying and decreasing small bowel transit time.
Absorption: Rapidly absorbed. Food may delay absorption. Bioavailability: Approx 15% (oral and rectal). Time to peak plasma concentration: Approx 30 min (oral); approx 1 hr (rectal).
Distribution: Enters breast milk (small amounts). Plasma protein binding: >90%.
Metabolism: Undergoes rapid and extensive hepatic metabolism via N-dealkylation by CYP3A4 isoenzyme and hydroxylation by CYP3A4, CYP1A2 and CYP2E1 isoenzymes.
Excretion: Via urine (approx 30%, as metabolites); faeces (approx 10%, as unchanged drug). Elimination half-life: Approx 7.5 hr.
MIMS Class
Antiemetics / GIT Regulators, Antiflatulents & Anti-Inflammatories
ATC Classification
A03FA03 – domperidone; Belongs to the class of propulsives. Used in the treatment of functional gastrointestinal disorders.;
