Description
Mechanism of Action
Diltiazem relaxes coronary vascular smooth muscles by inhibiting influx of calcium ions during depolarisation of the vascular smooth muscles and myocardium. It increases myocardial O2 delivery in patients with vasospastic angina and inhibits cardiac conduction, particularly at the SA and AV nodes.
Absorption: Rapidly and almost completely absorbed from the GI tract (oral).
Distribution: Enters breast milk. Protein-binding: 80%.
Metabolism: Hepatic: Extensive first-pass effect; yields desacetyldiltiazem (posseses 25-50% of the activity of the parent drug).
Excretion: Via urine (2-4% as unchanged and metabolites), via bile (remaining metabolites); 3-5 hr (elimination half-life).
MIMS Class
Anti-Anginal Drugs / Calcium Antagonists
ATC Classification
C08DB01 – diltiazem; Belongs to the class of benzothiazepine derivative selective calcium-channel blockers with direct cardiac effects. Used in the treatment of cardiovascular diseases.;
