Description
Mechanism of Action
Dexamethasone is a synthetic glucocorticoid which decreases inflammation by inhibiting the migration of leukocytes and reversal of increased capillary permeability. It suppresses normal immune response.
Onset: As acetate: Prompt.
Duration: 72 hr.
Absorption: Readily absorbed from the GI tract (Oral).
Distribution: Readily crosses the placenta. Protein binding: About 77%.
Metabolism: Hepatic.
Excretion: Via urine (65% of the dose within 24 hr). Half-life: About 190 min.
MIMS Class
Corticosteroid Hormones / Eye Corticosteroids / Topical Corticosteroids
ATC Classification
D10AA03 – dexamethasone; Belongs to the class of topical corticosteroids used in the treatment of acne.;
S02BA06 – dexamethasone; Belongs to the class of corticosteroids used in the treatment of inflammation of the ear.;
D07XB05 – dexamethasone; Belongs to the class of moderately potent (group II) corticosteroids in other combinations. Used in the treatment of dermatological diseases.;
A01AC02 – dexamethasone; Belongs to the class of local corticosteroid preparations. Used in the treatment of diseases of the mouth.;
S03BA01 – dexamethasone; Belongs to the class of corticosteroids used in ophthalmologic and otologic preparations.;
R01AD03 – dexamethasone; Belongs to the class of topical corticosteroids used for prophylaxis and treatment of allergic rhinitis.;
S01CB01 – dexamethasone; Belongs to the class of corticosteroids/antiinfectives/mydriatics combinations. Used in the treatment of eye diseases.;
D07AB19 – dexamethasone; Belongs to the class of moderately potent (group II) corticosteroids. Used in the treatment of dermatological diseases.;
S01BA01 – dexamethasone; Belongs to the class of corticosteroids. Used in the treatment of inflammation of the eye.;
H02AB02 – dexamethasone; Belongs to the class of glucocorticoids. Used in systemic corticosteroid preparations.;
C05AA09 – dexamethasone; Belongs to the class of products containing corticosteroids for topical use. Used in the treatment of hemorrhoids and anal fissures.;
