Description
Mechanism of Action
Clindamycin inhibits protein synthesis by reversibly binding to the 50S subunit of the ribosomal thus blocking the transpeptidation or translocation reactions of susceptible organisms resulting to stunted cell growth.
Absorption: 90% absorbed from the GI tract (oral), absorbed from the skin (topical), systemically (intravaginal); rate of absorption may be reduced by the presence of food.
Distribution: Body tissues and fluids (wide), bone, bile (high concentrations), leukocytes, macrophages; crosses the placenta and enters breast milk. Protein-binding: >>90%
Metabolism: Hepatic; converted to N-demethyl and sulfoxide metabolites and some inactive metabolites.
Excretion: Via urine (10% as active drug or metabolites), via faeces (4% as inactive metabolites); 2-3 hr (elimination half-life), may be prolonged in preterm neonates and severe renal impairment.
MIMS Class
Acne Treatment Preparations / Preparations for Vaginal Conditions / Other Antibiotics
ATC Classification
G01AA10 – clindamycin; Belongs to the class of antibiotics. Used in the treatment of gynecological infections.;
D10AF01 – clindamycin; Belongs to the class of topical antiinfective preparations used in the treatment of acne.;
J01FF01 – clindamycin; Belongs to the class of lincosamides. Used in the systemic treatment of infections.;
