Butamirate Citrate 50mg Tablet (NYSECOD *) 20s

228.00

Only 25 left in stock (can be backordered)

SKU: 02032022144957 Category:

Description

Indications

Non-productive cough.

Dosage

Adult : PO As 50 mg tab: 2 or 3 tabs at 8- or 12-hour interval. As 7.5 mg/5 mL syr: 15 mL up to 4 times/day.

Dosage Details

Oral
Non-productive cough

Adult: As 50 mg tab: 2 or 3 tabs daily at intervals of 8 or 12 hours. As 7.5 mg/5 mL syr: 15 mL up to 4 times daily.

Contraindications

Children <18 years. 1st trimester of pregnancy.

Special Precautions

Renal and hepatic impairment. Pregnancy (2nd to 3rd trimester) and lactation.

Adverse Drug Reactions

Significant: Somnolence, dizziness.
Gastrointestinal disorders: Diarrhoea, nausea.
Skin and subcutaneous tissue disorders: Urticaria, rash.

Patient Counselling

This drug may cause dizziness and somnolence, if affected, do not drive or operate machinery.

Overdosage

Symptoms: Drowsiness, dizziness, nausea, vomiting, diarrhoea, hypotension. Management: Symptomatic treatment. Administer activated charcoal or saline laxative, or perform gastric lavage. Monitor vital functions.

Drug Interactions

Concomitant use of expectorants may lead to retention of mucous in the respiratory system, which can increase the risk of bronchospasm and airway infection. 

Mechanism of Action

Description: Butamirate is a non-narcotic antitussive which presents nonspecific anticholinergic and antispasmodic effect, facilitating respiration. It acts centrally by diminishing the tussigenic reflex, and peripherally via a bronchospasmolytic activity enhanced by an anti-inflammatory action.
Pharmacokinetics: 
Absorption: Rapidly and completely absorbed from the gastrointestinal tract. Time to peak plasma concentration: Approx 1.5 hours.
Distribution: Plasma protein binding: Approx 95%
Metabolism: Undergoes hydrolysis to phenyl-2-butyric acid and diethylaminoethoxyethanol.
Excretion: Primarily via kidneys as metabolites. Plasma elimination half-life: Approx 13 hours.

Storage

Store below 30°C. Protect from light.

MIMS Class

Cough & Cold Preparations

ATC Classification

R05DB13 – butamirate ; Belongs to the class of other cough suppressants.

Additional information

location

davao, cdo, dipolog, butuan