Description
Mechanism of Action
Atenolol is a competitive cardioselective β1-blocker and does not have effect on β2-receptors except in high doses. It reduces resting and exercise-induced heart rate as well as myocardial contractility.
Onset: 2-4 hr (oral).
Duration: 12-24 hr.
Absorption: Rapidly but incompletely absorbed from the GI tract (approx 50%). Time to peak plasma concentration: 2-4 hr (oral).
Distribution: Enters breast milk, crosses the placenta and blood-brain barrier (small amounts). Plasma protein binding: 6-16%.
Metabolism: Undergoes minimal hepatic metabolism.
Excretion: Via urine (40% as unchanged drug); faeces (50%). Plasma half-life: Approx 6-7 hr.
MIMS Class
Beta-Blockers / Anti-Anginal Drugs
ATC Classification
C07AB03 – atenolol; Belongs to the class of selective beta-blocking agents. Used in the treatment of cardiovascular diseases.;
