Description
Mechanism of Action
Aminophylline is a combination of theophylline and ethylenediamine. Ethylenediamine is inactive; it increases the solubility of theophylline in water. Theophylline relaxes bronchial smooth muscle. Suggested mechanisms are an increase in intracellular cAMP through inhibition of phosphodiesterase; adenosine receptor antagonism, prostaglandin antagonism and effects on intracellular calcium.
Absorption: Rate of absorption delayed by food.
Distribution: Crosses the placenta and enters breast milk.
Metabolism: Undergoes hepatic metabolism.
Excretion: Via urine.
MIMS Class
Antiasthmatic & COPD Preparations
ATC Classification
R03DA05 – aminophylline; Belongs to the class of xanthines. Used in the systemic treatment of obstructive airway diseases.;
