Description
Mechanism of Action
Amikacin binds to 30S ribosomal subunits of susceptible bacteria, thus inhibiting its protein synthesis.
Distribution: Detected in body tissues and fluids after inj; crosses the placenta but does not readily penetrate the CSF. Significant amounts penetrate the blood-brain barrier in children with meningitis.
Excretion: Via the urine by glomerular filtration (within 24 hr); 2-3 hr (elimination half-life).
MIMS Class
Aminoglycosides
ATC Classification
J01GB06 – amikacin; Belongs to the class of other aminoglycosides. Used in the systemic treatment of infections.;
S01AA21 – amikacin; Belongs to the class of antibiotics. Used in the treatment of eye infections.;
D06AX12 – amikacin; Belongs to the class of other topical antibiotics used in the treatment of dermatological diseases.;
