Description
Mechanism of Action
Tetracycline exhibits its bacteriostatic action by reversibly binding to the 30S subunits of the ribosome, thus preventing protein synthesis and arresting cell growth. It has a broad spectrum of antimicrobial activity including Chlamydiaceae, Mycoplasma spp.,Rickettsia spp., spirochaetes, many aerobic and anaerobic gm+ve and gm-ve pathogenic bacteria and some protozoa.
Absorption: Incompletely absorbed from the GI tract. Bioavailability: Approx 60-80%. Absorption is reduced by food and milk. Time to peak plasma concentration: Approx 1.5-4 hr.
Distribution: Widely distributed to body tissues and fluids, w/ relatively low concentrations in CSF. Crosses the placenta and enters breast milk. Plasma protein binding: 20-65%.
Excretion: Via urine as unchanged drug (60%) and faeces as active form. Elimination half-life: 8-11 hr.
MIMS Class
Tetracyclines
ATC Classification
D06AA04 – tetracycline; Belongs to the class of topical tetracycline and derivatives agents used in the treatment of dermatological diseases.;
J01AA07 – tetracycline; Belongs to the class of tetracyclines. Used in the systemic treatment of infections.;
S01AA09 – tetracycline; Belongs to the class of antibiotics. Used in the treatment of eye infections.;
S03AA02 – tetracycline; Belongs to the class of antiinfectives used in ophthalmologic and otologic preparations.;
A01AB13 – tetracycline; Belongs to the class of local antiinfective and antiseptic preparations. Used in the treatment of diseases of the mouth.;
S02AA08 – tetracycline; Belongs to the class of antiinfectives used in the treatment of ear infections.;
