Description
Mechanism of Action
Loratadine is a non-sedating antihistamine. It works by selectively binding to peripheral histamine H1-receptors on effector cells.
Onset: 1-3 hr.
Duration: >24 hr.
Absorption: Absorbed rapidly from the GI tract. Food delays time to peak plasma concentration and increases bioavailability. Time to peak plasma concentration: Approx 1 hr.
Distribution: Enters breast milk. Plasma protein binding: Approx 98%.
Metabolism: Undergoes extensive hepatic metabolism via CYP2D6 and CYP3A4 to desloratadine (major metabolite).
Excretion: Via urine and faeces (as metabolites). Mean elimination half-life: 8.4 hr (loratadine) and 28 hr (desloratadine).
MIMS Class
Antihistamines & Antiallergics
ATC Classification
R06AX13 – loratadine; Belongs to the class of other antihistamines for systemic use
