Description
Mechanism of Action
Loperamide inhibits peristalsis and prolongs transit time by acting directly on intestinal wall muscles. It also reduces faecal volume, increases viscosity and decreases fluid and electrolyte loss.
Onset: 0.5-1 hr.
Absorption: Absorbed from the GI tract. Peak plasma concentrations achieved after 2.5 hr (oral solution) or 4-5 hr (capsule).
Excretion: Excreted in the urine (<2%) and faeces (30% as unchanged drug). Elimination half life of around 10.8 hr.
MIMS Class
Antidiarrheals
ATC Classification
A07DA03 – loperamide; Belongs to the class of antipropulsives. Used in the treatment of diarrhea.
