Description
Mechanism of Action
Levofloxacin exerts antibacterial action by inhibiting bacterial topoisomerase IV and DNA gyrase, the enzymes required for DNA replication, transcription repair and recombination. It has in vitro activity against a wide range of gram-negative and gram-positive microorganisms.
Absorption: Rapid and complete absorption from the GIT (oral); peak plasma concentrations within 1-2 hr.
Distribution: Widely distributed in bronchial mucosa, lungs; CSF (relatively poor). Protein-binding: 30-40%.
Metabolism: Limited.
Excretion: Mainly via urine (largely as unchanged drug); 6-8 hr (elimination half-life).
MIMS Class
Eye Anti-Infectives & Antiseptics / Quinolones
ATC Classification
S01AE05 – levofloxacin; Belongs to the class of quinolone antiinfectives. Used in the treatment of eye infections.;
J01MA12 – levofloxacin; Belongs to the class of fluoroquinolones. Used in the systemic treatment of infections.;
