Description
Mechanism of Action
Ibuprofen inhibits synthesis of prostaglandins in body tissues by inhibiting cyclooxygenase-1 and 2. It has anti-inflammatory, analgesic and antipyretic properties.
Onset: Analgesic: 30-60 min. Anti-inflammatory: ≤7 days (oral).
Duration: 4-6 hr (oral).
Absorption: Rapidly absorbed from the GI tract. Topical formulation is partially absorbed to the skin. Food may reduce the rate of absorption. Time to peak plasma concentration: 1-2 hr.
Distribution: Plasma protein binding: 90-99%.
Metabolism: Hepatic via oxidation.
Excretion: Via urine (primarily as metabolites, 1% as unchanged drug), and faeces (small amount). Plasma half-life: Approx 2 hr.
MIMS Class
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) / Other Cardiovascular Drugs
ATC Classification
G02CC01 – ibuprofen; Belongs to the class of antiinflammatory products for vaginal administration used in the treatment and prevention of inflammation.;
M02AA13 – ibuprofen; Belongs to the class of non-steroidal antiinflammatory preparations for topical use. Used in the treatment of joint and muscular pains.;
C01EB16 – ibuprofen; Belongs to the class of other cardiac preparations.;
M01AE01 – ibuprofen; Belongs to the class of propionic acid derivatives of non-steroidal antiinflammatory and antirheumatic products.;
