Description
Mechanism of Action
Epinephrine, an active principle of the adrenal medulla, is a direct-acting sympathomimetic. It stimulates α- and β-adrenergic receptors resulting in relaxation of smooth muscle of the bronchial tree, cardiac stimulation and dilation of skeletal muscle vasculature. It is frequently added to local anaesthetics to retard diffusion and limit absorption, to prolong the duration of effect and to lessen the danger of toxicity.
Onset: SC: approx 5-10 min; inhalation: approx 1 min; conjunctival instillation: IOP declines approx 1 hr.
Duration: Ocular effect: 12-24 hrs.
MIMS Class
Cardiac Drugs / Antiasthmatic & COPD Preparations / Antiglaucoma Preparations
ATC Classification
A01AD01 – epinephrine; Belongs to the class of other agents for local oral treatment.;
S01EA01 – epinephrine; Belongs to the class of sympathomimetics used in the treatment of glaucoma. ;
C01CA24 – epinephrine; Belongs to the class of adrenergic and dopaminergic cardiac stimulants excluding glycosides. Used in the treatment of heart failure.;
R01AA14 – epinephrine; Belongs to the class of topical sympathomimetic agents used as nasal decongestants.;
B02BC09 – epinephrine; Belongs to the class of local hemostatics. Used in the treatment of hemorrhage.;
R03AA01 – epinephrine; Belongs to the class of adrenergic inhalants, alpha- and beta-adrenoreceptor agonists. Used in the treatment of obstructive airway diseases.;
