Description
Mechanism of Action
Dopamine stimulates dopaminergic receptors at lower doses producing renal and mesenteric vasodilation while at higher doses stimulate both dopaminergic and β-adrenergic receptors producing cardiac stimulation and renal vasodilation. It increases heart rate and force of contraction. At low infusion rates vasodilatation occurs in the renal, mesenteric, coronary and cerebral beds. At higher rates vasoconstriction in skeletal muscles and a rise in BP.
Absorption: Inactivated in the GI tract and body (oral).
Metabolism: Into dopamine-related products; converted to noradrenaline.
Excretion: Eliminated as metabolic products of noradrenaline; 2 min (elimination half-life).
MIMS Class
Cardiac Drugs
ATC Classification
C01CA04 – dopamine; Belongs to the class of adrenergic and dopaminergic cardiac stimulants excluding glycosides. Used in the treatment of heart failure.;
