Description
Mechanism of Action
Clarithromycin inhibits protein synthesis by binding to 50s ribosomal subunits of susceptible organisms. It has activity against susceptible streptococci and staphylococci as well as other species including B. catarrhalis, L. spp, C. trachomatis and U. urealyticum.
Absorption: Rapidly absorbed from the GI tract (oral).
Distribution: Widely distributed (concentrations exceed those in serum); enters the breast milk.
Metabolism: Hepatic (extensive); converted to 14-hydroxyclarithromycin and other metabolites.
Excretion: Via the bile into the faeces; via the urine (20-30% as unchanged, 10-15% as 14-hydroxyclarithromycin and other metabolites).3-4 hr and 5-7 hr (elimination half-life)
MIMS Class
Macrolides
ATC Classification
J01FA09 – clarithromycin; Belongs to the class of macrolides. Used in the systemic treatment of infections.
