Description
Mechanism of Action
Cefaclor binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. It has bactericidal activity against gm-ve bacteria including E. coli, S. pneumoniae, N. gonorrhoea, P. mirabilis and H. influenzae.
Absorption: Well absorbed from the GIT (oral); rate but not extent of absorption is altered by food.
Distribution: Widely distributed; crosses the placenta and enters breast milk (low concentrations). Protein-binding: 25%
Excretion: Via the urine by the kidneys within 8 hrs (as 85% unchanged); the greater part of the dose within 2 hrs. Elimination half-life: 0.5-1 hr, slightly prolonged in renal impairment. May be removed by haemodialysis.
MIMS Class
Cephalosporins
ATC Classification
J01DC04 – cefaclor; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.;
