Description
Mechanism of Action
Carbamazepine reduces polysynaptic responses and blocks post-tetanic potentiation. It is effective in partial and generalised convulsions as well as in mixed types but not in petit mal seizures. It reduces or abolishes pain in trigeminal and glossopharyngeal neuralgia.
Absorption: Slowly and irregularly absorbed from the GI tract (oral).
Distribution: Crosses the placenta; enters breast milk. Protein-binding: 75%. Well distributed in the body.
Metabolism: Hepatic; converted to its metabolites.
Excretion: Urine (as metabolites), faeces; 5-26 hr (elimination half-life).
MIMS Class
Anticonvulsants
ATC Classification
N03AF01 – carbamazepine; Belongs to the class of carboxamide derivatives antiepileptic.;
