Description
Indications |
Non-productive cough. |
Dosage |
Adult : PO As 50 mg tab: 2 or 3 tabs at 8- or 12-hour interval. As 7.5 mg/5 mL syr: 15 mL up to 4 times/day. |
Dosage Details |
Oral Non-productive cough Adult: As 50 mg tab: 2 or 3 tabs daily at intervals of 8 or 12 hours. As 7.5 mg/5 mL syr: 15 mL up to 4 times daily. |
Contraindications |
Children <18 years. 1st trimester of pregnancy. |
Special Precautions |
Renal and hepatic impairment. Pregnancy (2nd to 3rd trimester) and lactation. |
Adverse Drug Reactions |
Significant: Somnolence, dizziness. Gastrointestinal disorders: Diarrhoea, nausea. Skin and subcutaneous tissue disorders: Urticaria, rash. |
Patient Counselling |
This drug may cause dizziness and somnolence, if affected, do not drive or operate machinery. |
Overdosage |
Symptoms: Drowsiness, dizziness, nausea, vomiting, diarrhoea, hypotension. Management: Symptomatic treatment. Administer activated charcoal or saline laxative, or perform gastric lavage. Monitor vital functions. |
Drug Interactions |
Concomitant use of expectorants may lead to retention of mucous in the respiratory system, which can increase the risk of bronchospasm and airway infection. |
Mechanism of Action |
Description: Butamirate is a non-narcotic antitussive which presents nonspecific anticholinergic and antispasmodic effect, facilitating respiration. It acts centrally by diminishing the tussigenic reflex, and peripherally via a bronchospasmolytic activity enhanced by an anti-inflammatory action. Pharmacokinetics: Absorption: Rapidly and completely absorbed from the gastrointestinal tract. Time to peak plasma concentration: Approx 1.5 hours. Distribution: Plasma protein binding: Approx 95% Metabolism: Undergoes hydrolysis to phenyl-2-butyric acid and diethylaminoethoxyethanol. Excretion: Primarily via kidneys as metabolites. Plasma elimination half-life: Approx 13 hours. |
Storage |
Store below 30°C. Protect from light. |
MIMS Class |
Cough & Cold Preparations |
ATC Classification |
R05DB13 – butamirate ; Belongs to the class of other cough suppressants. |
