Description
Mechanism of Action
Benzylpenicillin has a bactericidal action against gram-positive bacteria, gram-negative cocci, some other gram-negative bacteria, spirochetes and actinomycetes. It inhibits final cross-linking stage of peptidoglycan production through binding and inactivation of transpeptidases on the inner surface of the bacterial cell membrane thus inhibiting bacterial cell wall synthesis. It is inhibited by penicillinase and other β-lactamases.
Absorption: Rapidly inactivated by gastric acid; up to about 30% is absorbed after oral admin.
Distribution: Widely distributed. 60% bound to plasma proteins.
Metabolism: Limited metabolism.
Excretion: Plasma half-life: about 30 min, may increase to 10 hr in renal impairment. Rapidly excreted in the urine.
MIMS Class
Penicillins
ATC Classification
S01AA14 – benzylpenicillin; Belongs to the class of antibiotics. Used in the treatment of eye infections.;
J01CE01 – benzylpenicillin; Belongs to the class of beta-lactamase sensitive penicillins. Used in the systemic treatment of infections.;
