Indications and Dosage

Oral
Diarrhoea

Adult: As 2×109 spores/5 mL oral suspension or 2×109 spores/capsule: 2-3 vials or capsules daily at 3-4 hours intervals.
Child: 1 month to 11 years As 2×109 spores/5 mL oral suspension: 1-2 vials daily at 3-4 hours intervals, diluting in sweetened water, milk, tea or orange juice.

Special Precautions

Immunocompromised patients (e.g. premature infants). Children. Pregnancy and lactation. Not intended for inj or administration in any other way.

Adverse Reactions

Immune system disorders: Hypersensitivity reactions (e.g. rash, urticaria, angioedema).

Patient Counseling Information

Administer in the interval between 1 dose of antibiotic and the next during antibiotic treatment.

Action

Description: Bacillus clausii, a probiotic, is a spore-forming bacterium part of the normal gut flora with no pathogenic properties. It inhibits the growth of pathogens in the gastrointestinal tract via 3 distinct mechanism: colonisation, immunostimulation and antimicrobial properties. Bacillus clausii spores have high resistance to acidic conditions of the stomach and can reach the intestinal tract intact wherein they are transformed into metabolically active vegetative cells; they also contribute to restore the balance of the intestinal bacterial flora. Bacillus clausii is also capable of producing vitamins, particularly the group B vitamins, which contribute to correct the dysvitaminosis caused by use of antibiotics and chemotherapeutic agents.

Storage

Oral suspension: Store below 30°C. Cap: Store below 25°C.

MIMS Class

Antidiarrheals

References

Jayanthi N and Ratna Sudha M. Bacillus clausii – The Probiotic of Choice in the Treatment of Diarrhoea. 5(4):1-4. doi: 10.4172/2157-7595.1000211. Accessed 18/07/2019

Anon. Bacillus clausii. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 18/07/2019.

Erceflora (Sanofi S.p.A.). MIMS Philippines. http://www.mims.com/philippines. Accessed 18/07/2019.